Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2

0453579 - ÚH 2016 RIV BG eng J - Journal Article
Melnikova, G.B. - Kuzhel, N.S. - Tolstaya, T.N. - Konstantinova, E.E. - Drozd, E.S. - Shisko, O.N. - Mokhort, T.G. - Antonova, N. - Říha, Pavel - Kowalczuk, A. - Koseva, N.
Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2.
Series on biomechanics. Roč. 29, č. 4 (2015), s. 12-19. ISSN 1313-2458
Institutional support: RVO:67985874
Keywords : red blood cells * nanoparticles * poly(acrylic acid) * elasticity modulus * atomic force microscopy
Subject RIV: BK - Fluid Dynamics
http://www.imbm.bas.bg/biomechanics/uploads/Archive2015-4/12-19_Melnikova-Konstantinova_et%20al_abstract-1_18.12.15.pdf

The influence of polyacrylic acid (PAA) derived nanoparticles, a star shaped macromolecules with/nhydrodynamic radius of 14 nm, on the structure and mechanical properties of red blood cells (RBCs) membranes in/npatients with diabetes mellitus type 2 by AFM method has been studied. Their behavior has been compared to that/nof linear PAAs with different degrees of polymerization. Significant changes in the structure of RBCs membranes/ndid not occur and traces of polymer chains or nanoparticles were not found. It was shown, that changes of the/nelasticity modulus were observed after cells incubated in the presence of linear PAA with Mn =20000 Da and/n225000 Da, due to the interaction of polymer chains with the components of the cell membrane. The star shaped/nNPs with Mn = 57000 Da lead to the smallest changes in the structure and properties cells membrane. Thus, these/nNPs can be recommended for drug delivery applications.
Permanent Link: http://hdl.handle.net/11104/0254339