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Holocentromeres in Rhynchospora are associated with genome-wide centromere-specific repeat arrays interspersed among euchromatin

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    0450286 - BC 2016 RIV US eng J - Journal Article
    Marques, A. - Ribeiro, T. - Neumann, Pavel - Macas, Jiří - Novák, Petr - Schubert, V. - Pellino, M. - Fuchs, J. - Ma, W. - Kuhlmann, M. - Brandt, R. - Vanzela, A.L.L. - Beseda, Tomáš - Šimková, Hana - Pedrosa-Harand, A. - Houben, A.
    Holocentromeres in Rhynchospora are associated with genome-wide centromere-specific repeat arrays interspersed among euchromatin.
    Proceedings of the National Academy of Sciences of the United States of America. Roč. 112, č. 44 (2015), s. 13633-13638. ISSN 0027-8424. E-ISSN 1091-6490
    R&D Projects: GA ČR GBP501/12/G090; GA MŠMT(CZ) LO1204
    Institutional support: RVO:60077344 ; RVO:61389030
    Keywords : Centromere * satellite DNA * holokinetic * chromosome
    Subject RIV: EB - Genetics ; Molecular Biology; EB - Genetics ; Molecular Biology (UEB-Q)
    Impact factor: 9.423, year: 2015

    Holocentric chromosomes lack a primary constriction, in contrast to monocentrics. They form kinetochores distributed along almost the entire poleward surface of the chromatids, to which spindle fibers attach. No centromere-specific DNA sequence has been found for any holocentric organism studied so far. It was proposed that centromeric repeats, typical for many monocentric species, could not occur in holocentrics, most likely because of differences in the centromere organization. Here we show that the holokinetic centromeres of the Cyperaceae Rhynchospora pubera are highly enriched by a centromeric histone H3 variant-interacting centromere-specific satellite family designated “Tyba” and by centromeric retrotransposons (i.e., CRRh) occurring as genome-wide interspersed arrays. Centromeric arrays vary in length from 3 to 16 kb and are intermingled with gene-coding sequences and transposable elements.
    Permanent Link: http://hdl.handle.net/11104/0251624

     
     
Number of the records: 1  

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