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Phenolic profiles, antioxidant capacity, and acetylcholinesterase inhibitory activity of eight South African seaweeds
- 1.0447312 - ÚEB 2016 RIV US eng J - Journal Article
Rengasamy, K.R.R. - Amoo, S.O. - Aremu, A.O. - Stirk, W.A. - Grúz, Jiří - Šubrtová, Michaela - Doležal, Karel - van Staden, J.
Phenolic profiles, antioxidant capacity, and acetylcholinesterase inhibitory activity of eight South African seaweeds.
Journal of Applied Phycology. Roč. 27, č. 4 (2015), s. 1599-1605. ISSN 0921-8971. E-ISSN 1573-5176
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : Alzheimer's disease * AChE inhibitors * Phenolics
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.372, year: 2015
In the search for new, safe, and natural sources as antioxidant and acetylcholinesterase (AChE) inhibitors, eight seaweeds were collected from the intertidal region in KwaZulu-Natal, South Africa and screened. Their total phenolic, flavonoid, and condensed tannin contents were determined, and the specific phenolic acids were identified. The highest total phenolics, flavonoids, and condensed tannin were recorded in Rhodomelopsis africana (7.89 mg gallic acid equivalents g(-1)), Halimeda cuneata (3.64 mg catechin equivalents g(-1)), and Codium duthieae (0.60 mg cyanide chloride equivalents g(-1)), respectively. Based on UHPLC-MS/MS, different concentrations of protocatechuic acid, p-hydroxybenzoic acid, and m-hydroxybenzoic acid were quantified in the seaweeds. The highest radical scavenging ability and oxygen radical absorbance capacity (ORAC) were observed in red Gelidium foliaceum (52.2 %) and green C. duthieae (44 mu mol TE g(-1)), respectively. In terms of AChE inhibition, the green H. cuneata exhibited greatest bioactivity (IC50 = 70 mu g mL(-1)). Overall, the findings suggest that these seaweeds could be potential candidates as new sources of natural antioxidant and AChE inhibitors.
Permanent Link: http://hdl.handle.net/11104/0249166
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