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Selected Ga-68-siderophores versus Ga-68-colloid and Ga-68-citrate: biodistribution and small animal imaging in mice

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    0446378 - ÚEB 2016 RIV CZ eng J - Journal Article
    Petřík, M. - Vlčková, A. - Nový, Z. - Urbánek, Lubor - Haas, H. - Decristoforo, C.
    Selected Ga-68-siderophores versus Ga-68-colloid and Ga-68-citrate: biodistribution and small animal imaging in mice.
    Biomedical Papers. Roč. 159, č. 1 (2015), s. 60-66. ISSN 1213-8118
    R&D Projects: GA MŠk(CZ) LO1304
    Institutional support: RVO:61389030
    Keywords : gallium-68 * siderophores * colloid
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 0.924, year: 2015

    Background. Ga-68-triacetylfusarinine C (TAFC) and Ga-68-ferrioxamine E (FOXE) show great potential to be used as highly sensitive and selective tracers for Aspergillus infection imaging. Here we report on a comparison of the ex vivo biodistribution and small animal imaging of Ga-68-TAFC and Ga-68-FOXE versus Ga-68-colloid and Ga-68-citrate as unspecific control in mice. Methods. The radiochemical purity of tested Ga-68 labelled tracers was determined by RP-HPLC or ITLC-SG. Ex vivo biodistribution was studied in normal DBA/2 mice 30 min and 90 min p.i_ Static and dynamic imaging were performed using mu PET/CT. Results. Ga-68-TAFC and Ga-68-FOXE showed rapid renal excretion and low blood values even 90 min p.i_ Ga-68-TAFC showed almost no retention in other organs while 68Ga-FOXE displayed some uptake in gastrointestinal tract. Ga-68-colloid and Ga-68-citrate revealed significantly different ex vivo biodistribution. Ga-68-colloid showed pronounced radioactivity retention in the liver, while Ga-68-citrate displayed high blood values and significant retention of radioactivity in highly perfused organs. Conclusions. From the results, both Ga-68-TAFC and Ga-68-FOXE have excellent and significantly different in vivo behaviour compared to Ga-68-colloid and Ga-68-citrate. Ga-68-TAFC in particular confirmed its great potential use as a specific tracer for Aspergillus infection imaging.
    Permanent Link: http://hdl.handle.net/11104/0248384
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