Prevention of early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice

0440707 - MBÚ 2015 RIV US eng J - Journal Article
Funda, David P. - Fundová, Petra - Hansen, A. K. - Buschard, K.
Prevention of early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.
PLoS ONE. Roč. 9, č. 4 (2014). ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR GA310/09/1640; GA MZd(CZ) NS10340
Institutional support: RVO:61388971
Keywords : gliadin * diabetes * diabetes 1 type * NOD mice
Subject RIV: EC - Immunology
Impact factor: 3.234, year: 2014

Induction of long-term tolerance to beta-cell autoantigens has been investigated both in animal models and in human tpe 1 diabetes in order to prevent the disease. As it was found in this study, intranasal gliadin also rescued a fraction of prediabetic NOd mice. In conclusion, in. vaccination with gliadin, an environmental antigen with possible etiological influnce in T1D, may represent a novel, safer strategy for prevention or ven early cure of T1D.
Permanent Link: http://hdl.handle.net/11104/0243831