Copper-mediated Synthesis of Mono- and Dichlorinated Diaryl Ethers

0429530 - ÚCHP 2015 RIV GB eng J - Journal Article
Čermák, Jan K. - Církva, Vladimír
Copper-mediated Synthesis of Mono- and Dichlorinated Diaryl Ethers.
Tetrahedron Letters. Roč. 55, č. 30 (2014), s. 4185-4188. ISSN 0040-4039. E-ISSN 1873-3581
Institutional support: RVO:67985858
Keywords : O-arylation * Chan-Lam coupling * kovats indices
Subject RIV: CC - Organic Chemistry
Impact factor: 2.379, year: 2014

An efficient synthesis of polychlorinated diphenyl ethers (PCDEs) using the Cu(OAc)2 catalyzed Chan–Lam coupling reaction is described. A library of all possible mono- and dichlorinated diphenyl ether congeners was prepared and characterized using MS, 1H, and 13C NMR spectroscopy, and Kovats retention indices. Our approach, using the optimized reaction conditions (i.e., reaction temperature, oxidizing atmosphere and base), significantly improves and simplifies the process compared to previously reported syntheses.
Permanent Link: http://hdl.handle.net/11104/0235307