Single cell analysis of caspase-3 in apoptotic and non-apoptotic cells during mouse limb development

0428307 - ÚIACH 2015 GB eng A - Abstract
Adamová, Eva - Klepárník, Karel - Matalová, E.
Single cell analysis of caspase-3 in apoptotic and non-apoptotic cells during mouse limb development.
Bone Abstracts. Roč. 3, - (2014), PP58. ISSN 2052-1219.
[European Calcified Tissue Society Congress /41./. 17.05.2014-20.05.2014, Praha]
R&D Projects: GA ČR GAP206/11/2377; GA ČR(CZ) GA14-28254S
Institutional support: RVO:68081715
Keywords : single cell analysis * caspase-3 * mouse limb development
Subject RIV: CB - Analytical Chemistry, Separation

Caspases belong to cysteine proteases participating in apoptosis and inflammation. However, there is recent evidence about their functions also in other events such as cell differentiation. This is supported also by our latest research of odontogenesis and osteogenesis. With the increasing interest in caspases due to their apoptosis-related therapies but also emerging non-apoptotic roles, exact evaluation of their impact at single cell level becomes challenging.
Permanent Link: http://hdl.handle.net/11104/0233657