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X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids

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    0424947 - UMG-J 2014 RIV US eng J - Journal Article
    Bhattacharyya, Tanmoy - Reifová, R. - Gregorová, Soňa - Šimeček, Petr - Gergelits, Václav - Mistrik, M. - Martincová, Iva - Piálek, Jaroslav - Forejt, Jiří
    X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids.
    PLoS Genetics. Roč. 10, č. 2 (2014), e1004088. ISSN 1553-7404
    R&D Projects: GA AV ČR Premium Academiae of the Academy of Sciences of the Czech Republic; GA MŠk(CZ) LD11079; GA ČR GA206/08/0640; GA MŠk ED1.1.00/02.0109
    Institutional support: RVO:68081766 ; RVO:68378050
    Keywords : hybrid sterility * meiotic asynapsis * chromosome substitution strains
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 8.167, year: 2013

    Genomes of newly emerging species restrict their gene exchange with related taxa in order to secure integrity. Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between closely related, sexually reproducing organisms. We showed that hybrid sterility between two closely related mouse subspecies is executed by a failure of meiotic synapsis of orthologous chromosomes in F1 hybrid males. The asynapsis of orthologous chromosomes occurred in meiosis of male and female hybrids, though only males were sterile due to trans-acting male-specific hybrid sterility genes. We located one of the two major hybrid sterility genes to a 4.7 Mb interval on Chromosome X, showed that it controls male sterility by modulating the extent of meiotic asynapsis and using the inter-subspecific chromosome substitution strains we refuted the simple interpretation of dominance theory of Haldane's rule. A new working hypothesis posits male sterility of mouse inter-subsubspecific F1 hybrids as a consequence of meiotic chromosome asynapsis caused by the cis-acting mismatch between orthologous chromosomes modulated by the trans-acting hybrid male sterility genes.
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