Regulation of cytoskeletal dynamics by phospholipase D and phosphatidic acid

0399937 - ÚEB 2014 RIV GB eng J - Journal Article
Pleskot, Roman - Li, J.J. - Žárský, Viktor - Potocký, Martin - Staiger, C.J.
Regulation of cytoskeletal dynamics by phospholipase D and phosphatidic acid.
Trends in Plant Science. Roč. 18, č. 9 (2013), s. 496-504. ISSN 1360-1385. E-ISSN 1878-4372
R&D Projects: GA ČR GA13-19073S
Institutional research plan: CEZ:AV0Z50380511
Keywords : cytoskeleton * microtubules * phosphatidic acid
Subject RIV: ED - Physiology
Impact factor: 13.479, year: 2013

Plants respond to diverse biotic and abiotic stimuli as well as to endogenous developmental cues. Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). PA is a key signaling intermediate in animals, but its targets in plants are relatively uncharacterized. Recent studies have demonstrated that the cytoskeleton is a major target of PLD-PA signaling and identified a positive feedback loop between actin turnover and PLD activity. Moreover, two cytoskeletal proteins, capping protein and MAP65-1, have been identified as PA-binding proteins regulating actin and microtubule organization and dynamics. In this review, we highlight the role of the PLD-PA module as an important hub for housekeeping and stress-induced regulation of membrane-associated cytoskeletal dynamics.
Permanent Link: http://hdl.handle.net/11104/0227071