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Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose

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    0399579 - ÚEB 2014 RIV GB eng J - Journal Article
    Dvořáková, Marcela - Nencka, Radim - Dejmek, Milan - Zborníková, Eva - Březinová, Anna - Přibylová, Marie - Pohl, Radek - Migaud, M. E. - Vaněk, Tomáš
    Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose.
    Organic & Biomolecular Chemistry. Roč. 11, č. 34 (2013), s. 5702-5713. ISSN 1477-0520. E-ISSN 1477-0539
    Institutional support: RVO:61389030 ; RVO:61388963
    Keywords : DEACETYLASES * FURANOSIDES * METABOLITE
    Subject RIV: CC - Organic Chemistry
    Impact factor: 3.487, year: 2013

    The non-hydrolyzable alkylcarbonate analogs of O-acetyl-ADP-ribose have been synthesized from the phosphorylated ribose derivatives after coupling with AMP morpholidate promoted by mechanical grinding. The analogs were assessed for their ability to inhibit the human sirtuin homolog SIRT1.
    Permanent Link: http://hdl.handle.net/11104/0226914

     
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