Life on magnets: stem cell networking on micro-magnet arrays

0396238 - FZÚ 2014 RIV US eng J - Journal Article
Zablotskyy, Vitaliy A. - Dejneka, Alexandr - Kubinová, Šárka - Le-Roy, D. - Dumas-Bouchiat, F. - Givord, D. - Dempsey, N. - Syková, Eva
Life on magnets: stem cell networking on micro-magnet arrays.
PLoS ONE. Roč. 8, č. 8 (2013), e70416. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR GAP304/11/0653; GA ČR(CZ) GAP304/12/1370
Grant - others:AV ČR(CZ) M100101219
Institutional support: RVO:68378271 ; RVO:68378041
Keywords : micro-magnet * stem cells
Subject RIV: BM - Solid Matter Physics ; Magnetism; FH - Neurology (UEM-P)
Impact factor: 3.534, year: 2013

Interactions between a micro-magnet array and living cells may guide the establishment of cell networks due to the cellular response to a magnetic field. To manipulate mesenchymal stem cells free of magnetic nanoparticles by a high magnetic field gradient, we used high quality micro-patterned NdFeB films around which the stray field’s value and direction drastically change across the cell body. Such micro-magnet arrays coated with parylene produce high magnetic field gradients that affect the cells in two main ways: i) causing cell migration and adherence to a covered magnetic surface andii) elongating the cells in the directions parallel to the edges of the micro-magnet.
Permanent Link: http://hdl.handle.net/11104/0224066