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Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group
- 1.0383763 - ÚBO 2013 RIV US eng J - Journal Article
Aliota, M. T. - Jones, S. A. - Dupuis, A. P. - Ciota, A. T. - Hubálek, Zdeněk - Kramer, L. D.
Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group.
PLoS ONE. Roč. 7, č. 6 (2012), e39387. ISSN 1932-6203. E-ISSN 1932-6203
Institutional support: RVO:68081766
Keywords : Insect-specific flaviviruses * Northeastern United-States * Culex pipiens
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.730, year: 2012
Rabensburg virus (RABV), a Flavivirus with similar to 76% nucleotide and 90% amino acid identity with representative members of lineage one and two West Nile virus (WNV), previously was isolated from Culex pipiens and Aedes rossicus mosquitoes in the Czech Republic, and phylogenetic and serologic analyses demonstrated that it was likely a new lineage of WNV. However, no direct link between RABV and human disease has been definitively established and the extent to which RABV utilizes the typical WNV transmission cycle is unknown. Herein, we evaluated vector competence and capacity for vertical transmission (VT) in Cx. pipiens; in vitro growth on avian, mammalian, and mosquito cells; and infectivity and viremia production in birds. RABV infection and replication only were detected on mosquito cells. Experimentally inoculated birds did not become infected. Cx. pipiens had poor peroral vector competence and a higher VT rate as compared to US-WNV in Cx. pipiens. As a result, we postulate that RABV is an intermediate between the mosquito-specific and horizontally transmitted flaviviruses.
Permanent Link: http://hdl.handle.net/11104/0213604
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Number of the records: 1