Crystallization, Spectral, Crystallographical, and Thermoanalytical Studies of Succinobucol Polymorphism

0380695 - ÚEB 2013 RIV US eng J - Journal Article
Jurček, Ondřej - Lahtinen, M. - Wimmer, Zdeněk - Drašar, P. - Kolehmainen, E.
Crystallization, Spectral, Crystallographical, and Thermoanalytical Studies of Succinobucol Polymorphism.
Journal of Pharmaceutical Sciences. Roč. 101, č. 5 (2012), s. 1794-1802. ISSN 0022-3549. E-ISSN 1520-6017
R&D Projects: GA MŠMT 2B06024; GA MŠMT(CZ) OC10001
Institutional research plan: CEZ:AV0Z50380511
Keywords : succinobucol * atherosclerosis * diabetes
Subject RIV: CC - Organic Chemistry
Impact factor: 3.130, year: 2012

Four different polymorphs, A, C, D, and E, of succinobucol were isolated and characterized by means of solid-state nuclear magnetic resonance spectroscopy, single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry, and attenuated total reflection-infrared spectroscopy. From a number of experiments, the same polymorphs (C, D, and E) and an equilibrium phase mixture B consisting of polymorphs C and D were repeatedly gained using different solvents or their mixtures. Although polymorph A was obtained directly from recrystallization only on few occasions, polymorphs C, D, and E proved to be metastable kinetic polymorphs, which slowly transform to a thermodynamically more stable form A during long-term storage. The single-crystal structures of polymorph C and D were determined by X-ray single-crystal diffraction.
Permanent Link: http://hdl.handle.net/11104/0211338