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Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally gamma-irradiated mice

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    0368838 - BFÚ 2012 RIV FR eng J - Journal Article
    Hofer, Michal - Pospíšil, Milan - Dušek, L. - Hoferová, Zuzana - Weiterová, Lenka
    Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally gamma-irradiated mice.
    Biomedicine & Pharmacotherapy. Roč. 65, č. 6 (2011), s. 427-431. ISSN 0753-3322
    R&D Projects: GA MO OVBIOFYZ20101; GA ČR(CZ) GA305/08/0158
    Grant - others:GA ČR(CZ) GAP303/11/0128
    Program:GA
    Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Keywords : hematopoiesis * cyclooxygenase-2 inhibition * Adenosine A3 receptor
    Subject RIV: BO - Biophysics
    Impact factor: 2.000, year: 2011

    We have found out that concommitant administration of a cycloxygenase-2 inhibitor, meloxicam, and an agonist of adenosine A3 receptor, IB-MECA, induces a significant potentiation of hematopoiesis-stimulating effects in sublethally gamma-irradiated mice in comparison with those caused by any of the drugs given alone.
    Permanent Link: http://hdl.handle.net/11104/0203067
     
Number of the records: 1