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Fast decline of hematopoiesis and uncoupling protein 2 content in human liver after birth: location of the protein in Kupffer cells

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    0142145 - FGU-C 20010164 RIV US eng J - Journal Article
    Brauner, Petr - Nibbelink, M. - Flachs, P. - Vítková, I. - Kopecký, P. - Mertelíková, Irena - Janderová, L. - Pénicaud, L. - Casteilla, L. - Plavka, R. - Kopecký, Jan
    Fast decline of hematopoiesis and uncoupling protein 2 content in human liver after birth: location of the protein in Kupffer cells.
    Pediatric Research. Roč. 49, č. 3 (2001), s. 440-447. ISSN 0031-3998
    R&D Projects: GA MŠk LN00A079; GA MZd NE4643
    Grant - others:Dvoustranná česko-francouzská spolupráce v oblasti vědy a výzkumu(XE) Barrande 98082-2
    Institutional research plan: CEZ:AV0Z5011922
    Keywords : hepatic hematopoiesis * uncoupling protein 2
    Subject RIV: FB - Endocrinology, Diabetology, Metabolism, Nutrition
    Impact factor: 3.289, year: 2001

    Hepatic hematopoiesis is prominent during fetal life and declines around birth. We have investigated whether mitochondrial uncoupling protein 2 (UCP2) could be used as a marker of this process in human neonates. UCP2 expression was high prenatal and declined after birth, while being expressed in liver macrophages. UCP2 is a novel marker for the development of macrophages in developing liver.
    Permanent Link: http://hdl.handle.net/11104/0039854
     

Number of the records: 1