0616879 - ÚMCH 2026 RIV US eng J - Journal Article
Elter, Johanna K. - Sedlák, F. - Palušák, T. - Bernardová, N. - Lobaz, Volodymyr - Tihlaříková, Eva - Neděla, Vilém - Šácha, Pavel - Hrubý, Martin
Solid lipid nanoparticles coated with glucosylated poly(2-oxazoline)s: a supramolecular toolbox approach.
Biomacromolecules. Roč. 26, č. 2 (2025), s. 861-882. ISSN 1525-7797. E-ISSN 1526-4602
R&D Projects: GA ČR(CZ) GA24-10814S; GA MŠMT(CZ) EH22_008/0004607; GA MŠMT LX22NPO5102
Grant - others:AV ČR(CZ) StrategieAV21/26
Program: StrategieAV
Institutional support: RVO:61389013 ; RVO:68081731 ; RVO:61388963
Keywords : solid lipid nanoparticles * glucosylated poly(2-oxazoline)s * polymer
OECD category: Polymer science; Electrical and electronic engineering (UPT-D); Biochemistry and molecular biology (UOCHB-X)
Impact factor: 5.5, year: 2023 ; AIS: 1.02, rok: 2023
Method of publishing: Open access
Result website:
https://pubs.acs.org/doi/10.1021/acs.biomac.4c01052DOI: https://doi.org/10.1021/acs.biomac.4c01052

Multifunctional polymers are interesting substances for the formulation of drug molecules that cannot be administered in their pure form due to their pharmacokinetic profiles or side effects. Polymer-drug formulations can enhance pharmacological properties or create tissue specificity by encapsulating the drug into nanocontainers, or stabilizing nanoparticles for drug transport. We present the synthesis of multifunctional poly(2-ethyl-2-oxazoline-co-2-glyco-2-oxazoline)s containing two reactive end groups, and an additional hydrophobic anchor at one end of the molecule. These polymers were successfully used to stabilize (solid) lipid nanoparticles ((S)LNP) consisting of tetradecan-1-ol and cholesterol with their hydrophobic anchor. While the pure polymers interacted with GLUT1-expressing cell lines mainly based on their physicochemical properties, especially via interactions of the hydrophobic anchor with membranous compartments of the cells, LNP-cell interactions hinted toward an influence of the glucosylation on particle–cell interactions. The presented LNP are therefore promising systems for the delivery of drugs into GLUT1-expressing cell lines.
Permanent Link: https://hdl.handle.net/11104/0364537
Research data: Biomacromolecules_Supporting Information
 
Scientific data in ASEP :
Solid lipid nanoparticles coated with glucosylated poly(2-oxazoline)s. A supramolecular toolbox approach - UV-VIS, dynamic light scattering (size distribution) and biological data from solid lipid nanoparticles coated with glucosylated poly(2-oxazoline)s