0602154 - FGÚ 2025 RIV CZ eng J - Journal Article
Bačáková, Lucie - Sedlář, Antonín - Musílková, Jana - Eckhardt, Adam - Žaloudíková, M. - Kolář, František - Maxová, H.
Mechanisms Controlling the Behavior of Vascular Smooth Muscle Cells in Hypoxic Pulmonary Hypertension.
Physiological Research. Roč. 73, Suppl.2 (2024), S569-S596. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MŠMT(CZ) EH22_008/0004562; GA ČR(CZ) GA22-00317S
Grant - others:AV ČR(CZ) AP2202
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:67985823
Keywords : vasoconstriction * remodeling * oxidation * extracellular matrix * endothelial cells * mast cells * smooth muscle cells * mesenchymal stem cells * therapy of hypoxic pulmonary hypertension
OECD category: Cell biology
Impact factor: 1.9, year: 2023 ; AIS: 0.394, rok: 2023
Method of publishing: Open access
Result website:
https://www.biomed.cas.cz/physiolres/pdf/2024/73_S569.pdf

DOI: https://doi.org/10.33549/physiolres.935394

Pulmonary hypertension is a complex and heterogeneous condition with five main subtypes (groups). This review focuses on pulmonary hypertension caused by chronic hypoxia (hypoxic pulmonary hypertension, HPH, group 3). It is based mainly on our own experimental work, especially our collaboration with the group of Professor Herget, whose fifth anniversary of death we commemorate. We have found that oxidation and degradation of the extracellular matrix (ECM) in vitro, in either the presence or the absence of pro-inflammatory cells, activate vascular smooth muscle cell (VSMC) proliferation. Significant changes in the ECM of pulmonary arteries also occurred in vivo in hypoxic rats, namely a decrease in collagen VI and an increase in matrix metalloproteinase 9 (MMP-9) in the tunica media, which may also contribute to the growth activation of VSMCs. The proliferation of VSMCs was also enhanced in their co-culture with macrophages, most likely due to the paracrine production of growth factors in these cells. However, hypoxia itself has a dual effect: on the one hand, it can activate VSMC proliferation and hyperplasia, but on the other hand, it can also induce VSMC hypertrophy and increased expression of contractile markers in these cells. The influence of hypoxia-inducible factors, microRNAs and galectin-3 in the initiation and development of HPH, and the role of cell types other than VSMCs (endothelial cells, adventitial fibroblasts) are also discussed.
Permanent Link: https://hdl.handle.net/11104/0359363