0601941 - FGÚ 2025 RIV CZ eng A - Abstract
Zouhar, Petr - Bardová, Kristina - Janovská, Petra - Kopecký, Jan
Alternative thermogenic mechanisms for prevention of obesity.
ABSTRACT BOOK Nencki-IPHYS-IOCB Scientific Meeting 2024. Praha: Ústav organické chemie a biochemie, 2024. s. 44-44.
[Nencki-IPHYS-IOCB Scientific Meeting 2024. 01.10.2024-03.10.2024, Liblice]
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:67985823
Keywords : thermogenic mechanisms * obesity * brown adipose tissue
OECD category: Endocrinology and metabolism (including diabetes, hormones)

It is hypothesised that the peripheral location and lack of rapid adrenergic regulation of muscles may result in greater energy expenditure for the same thermogenic effect as observed in brown adipose tissue. This may be a contributing factor to the obesity resistance observed in mice utilising this mechanism. Our ongoing investigation focuses on the putative molecular mechanisms that distinguish muscle physiology of A/J and C57BL/6 mice, such as sarcolipin-dependent uncoupling of the endoplasmic calcium pump and changes in the formation of mitochondrial supercomplexes. A detailed understanding of these mechanisms could reveal new pharmacologic targets for the prevention of obesity.
Permanent Link: https://hdl.handle.net/11104/0359160