0598585 - ÚOCHB 2025 RIV US eng J - Journal Article
Mrázková, Lucie - Lubos, Marta - Voldřich, Jan - Kužmová, Erika - Zrubecká, D. - Gwozdiaková, Petra - Buděšínský, Miloš - Asai, Seiya - Marek, Aleš - Pícha, Jan - Tencerová, Michaela - Ferenčáková, Michaela - Barrera Alquicer, Glenda - Kaminský, Jakub - Jiráček, Jiří - Žáková, Lenka
The final walk with preptin.
PLoS ONE. Roč. 19, č. 9 (2024), č. článku e0309726. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GA19-14069S; GA ČR(CZ) GA22-12243S; GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : IGF-2 * prohormone * function * peptide
OECD category: Biochemistry and molecular biology
Impact factor: 2.9, year: 2023 ; AIS: 0.886, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1371/journal.pone.0309726DOI: https://doi.org/10.1371/journal.pone.0309726

The precise physiological role of preptin, a 34-amino acid peptide derived from pro-IGF2, remains enig-matic. To address this knowledge gap, we conducted comprehensive comparative activity evaluations alongside native human, mouse and rat preptin and their fragments. Contrary to previous indications of broad biological activity, our thorough analyses across diverse cell types revealed no significant biological activity associated with preptin or its analogs. Rather than acting independently, the observed effects of preptin may arise from experimental conditions, elevated preptin concentrations, or interactions with related molecules such as IGF2.
Permanent Link: https://hdl.handle.net/11104/0356195


Research data: OSF