Surface plasmon resonance biosensor with anti-crossing modulation readout

0587296 - FZÚ 2025 RIV NL eng J - Journal Article
Hasler, R. - Cattozzo Mor, Dario - Aktug, Gizem - Fossati, Stefan - Vu, V.T. - Tamayo, A. - Giordani, E. - Ricciardi, E. - Giacomini, P. - Perutka, J. - Önder, K. - Kleber, Ch. - Samori, P. - Huang, Ch.-J. - Dostálek, Jakub
Surface plasmon resonance biosensor with anti-crossing modulation readout.
Sensors and Actuators B - Chemical. Roč. 417, Oct (2024), č. článku 136163. E-ISSN 0925-4005
R&D Projects: GA ČR(CZ) GC22-30456J; GA MŠMT(CZ) EH22_008/0004596
EU Projects: European Commission(XE) 101046217 - VerSiLiB
Institutional support: RVO:68378271
Keywords : grating-coupled surface plasmon resonance * multi-periodic grating * nanoimprint lithography * biosensor * multiplexing * antifouling biointerface
OECD category: Optics (including laser optics and quantum optics)
Impact factor: 8.4, year: 2022
Method of publishing: Open access

A novel approach to surface plasmon resonance (SPR) biosensors providing simplified label-free monitoring of biomolecular affinity binding events is reported. It is based on the interrogation of anti-crossing surface plasmon modes traveling along opposite interfaces of a thin metal film on the top of a tailored multi-periodic grating structure. It allows for diffraction-based backside excitation of surface plasmons without the need of optical matching of the sensor chip to a prism and it allows avoiding of optical probing through the analyzed liquid sample. In conjunction with low angular dispersion of resonantly excited surface plasmon modes, it provides sensitive and versatile optical interrogation of SPR changes associated with biomolecular binding-induced refractive index variations.
Permanent Link: https://hdl.handle.net/11104/0354546


Research data: Zenodo