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Synthesis of Fluorinated Methyl β-Lactosides
- 1.0586569 - ÚCHP 2025 CZ eng K - Conference Paper (Czech conference)
Krčil, Aleš
Synthesis of Fluorinated Methyl β-Lactosides.
Proceedings of Abstracts. Prague: Institute of Chemical Process Fundamentals of the CAS, v. v. i., 2024 - (Orvalho, S.; Wagner, Z.), s. 23-24. ISBN 978-80-86186-32-0.
[Bažant Postgraduate Conference 2024. Prague (CZ), 05.06.2024-06.06.2024]
R&D Projects: GA ČR(CZ) GA23-05146S
Institutional support: RVO:67985858
Keywords : flurinated carbohydrates * galectin * deoxyfluorination
OECD category: Organic chemistry
In my contribution, I will describe the synthesis of a complete series of mono-deoxyfluorinated methyl β-lactosides (1–7). Their affinity towards hgals will be determined by analytical method ELISA. The synthesis relies on monosaccharide building blocks, which serves as key intermediates that are transformed into the target products through glycosylation followed by final deprotection steps.
Permanent Link: https://hdl.handle.net/11104/0354030
File Download Size Commentary Version Access SbornikBazant2024.pdf 5 1.2 MB Publisher’s postprint open-access
Number of the records: 1