Development of Continuous Technology for the Preparation of Pharmaceuticals

0586554 - ÚCHP 2025 CZ eng K - Conference Paper (Czech conference)
Jaklová, Natalie
Development of Continuous Technology for the Preparation of Pharmaceuticals.
Proceedings of Abstracts. Prague: Institute of Chemical Process Fundamentals of the CAS, v. v. i., 2024 - (Orvalho, S.; Wagner, Z.), s. 13-14. ISBN 978-80-86186-32-0.
[Bažant Postgraduate Conference 2024. Prague (CZ), 05.06.2024-06.06.2024]
Institutional support: RVO:67985858
Keywords : continualization * ultrasound * pharmaceuticals
OECD category: Chemical process engineering

The present research focuses on the transition of a batch reaction assisted by phase transfer catalyst (PTC) into continuous process. The first reaction studied was an N-alkylation reaction with methyl ester of the 1-methyl-10α-methoxydihydrolysergic acid (MeLUME) as product. MeLUME is one of the intermediates in synthesis of drug Nicergoline. The N-alkylation occurs in two different immiscible phases and the bridge between these phases is the phase transfer catalyst. The study was performed in several different continuous flow apparatuses. The best results were obtained in a capillary reactor, with assistance of ultrasound.
Permanent Link: https://hdl.handle.net/11104/0354017