Thermoresponsive and photocrosslinkable poly(2-alkyl-2-oxazoline) toolbox – customizable ultralow-fouling hydrogel coatings for blood plasma environments

0586293 - FZÚ 2025 RIV US eng J - Journal Article
Wiesner (née Diehl), F. - Petri, C. - Hageneder, S. - Kunzler, C. - Klees, S. - Frank, P. - Pertiller, M. - Dostálek, Jakub - Knoll, W. - Jonas, U.
Thermoresponsive and photocrosslinkable poly(2-alkyl-2-oxazoline) toolbox – customizable ultralow-fouling hydrogel coatings for blood plasma environments.
Macromolecular Rapid Communications. Roč. 45, č. 4 (2024), č. článku 2300549. ISSN 1022-1336. E-ISSN 1521-3927
R&D Projects: GA ČR(CZ) GC22-30456J
Institutional support: RVO:68378271
Keywords : antifouling thermoresponsive hydrogel coatings * betaines * blood plasma * photocrosslinkable poly(2-oxazoline)s * SPR/OWS
OECD category: Biophysics
Impact factor: 4.6, year: 2022
Method of publishing: Open access

This study focuses on developing surface coatings with excellent antifouling properties, crucial for applications in the medical, biological, and technical fields, for materials and devices in direct contact with living tissues and bodily fluids such as blood. This approach combines thermoresponsive poly(2-alkyl-2-oxazoline)s, known for their inherent protein-repellent characteristics, with established antifouling motifs based on betaines. The polymer framework is constructed from various monomer types, including a novel benzophenone-modified 2-oxazoline for photocrosslinking and an azide-functionalized 2-oxazoline, allowing subsequent modification with alkyne-substituted antifouling motifs through copper(I)-catalyzed azide-alkyne cycloaddition.
Permanent Link: https://hdl.handle.net/11104/0353864