Anorexigenic neuropeptides as anti-obesity and neuroprotective agents: exploring the neuroprotective effects of anorexigenic neuropeptides

0586184 - FGÚ 2025 RIV GB eng J - Journal Article
Strnadová, V. - Pačesová, A. - Charvát, V. - Šmotková, Z. - Železná, B. - Kuneš, Jaroslav - Maletínská, L.
Anorexigenic neuropeptides as anti-obesity and neuroprotective agents: exploring the neuroprotective effects of anorexigenic neuropeptides.
Bioscience Reports. Roč. 44, č. 4 (2024), č. článku BSR20231385. ISSN 0144-8463. E-ISSN 1573-4935
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA TA ČR(CZ) TN02000109
Institutional support: RVO:67985823
Keywords : amphetamine-regulated transcript * prolactin-releasing peptide * melanocyte-stimulating hormone
OECD category: Pharmacology and pharmacy
Impact factor: 4, year: 2022
Method of publishing: Open access
https://doi.org/10.1042/BSR20231385

Since 1975, the incidence of obesity has increased to epidemic proportions, and the number of patients with obesity has quadrupled. Obesity is a major risk factor for developing other serious diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular diseases. Recent epidemiologic studies have defined obesity as a risk factor for the development of neurodegenerative diseases, such as Alzheimer's disease (AD) and other types of dementia. Despite all these serious comorbidities associated with obesity, there is still a lack of effective antiobesity treatment. Promising candidates for the treatment of obesity are anorexigenic neuropeptides, which are peptides produced by neurons in brain areas implicated in food intake regulation, such as the hypothalamus or the brainstem. These peptides efficiently reduce food intake and body weight. Moreover, because of the proven interconnection between obesity and the risk of developing AD, the potential neuroprotective effects of these two agents in animal models of neurodegeneration have been examined. The objective of this review was to explore anorexigenic neuropeptides produced and acting within the brain, emphasizing their potential not only for the treatment of obesity but also for the treatment of neurodegenerative disorders.
Permanent Link: https://hdl.handle.net/11104/0353771