Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) A Review

0586043 - ÚEB 2025 RIV IR eng J - Journal Article
Onder, F. C. - Kalin, S. - Sahin, N. - Davutlar, G. - Abusharkh, K. A.N. - Maraba, O. - Hal, R. S. - Ay, M. - Nahar, Lutfun - Sarker, S. D.
Major Bioactive Prenylated Flavonoids from Humulus lupulus L., Their Applications in Human Diseases and Structure-Activity Relationships (SAR) A Review.
Pharmaceutical Sciences. Roč. 30, č. 1 (2024), s. 1-20. ISSN 1735-403X. E-ISSN 2383-2886
Institutional support: RVO:61389030
Keywords : Cancer * Humulus lupulus L. * In silico * Phytotherapeutics * Preclinical trial * Xanthohumol
OECD category: Pharmacology and pharmacy
Impact factor: 1.7, year: 2022
Method of publishing: Open access
https://doi.org/10.34172/PS.2023.18

In recent years, the incidence of cancers, inflammatory diseases, Alzheimer's disease, glucose metabolism disorder and diabetes has increased alarmingly which demands more research into the discovery of new drug candidates to treat these human diseases. Main phytochemicals from Humulus lupulus L. (hops) have been demonstrated to have positive impacts on human health, and prenylated flavonoids are one of the major groups of bioactive phytochemicals found in this plant. Thus, this review summarizes the role of major prenylated components in hops in human diseases including cancer, inflammation and viral infections. In silico studies of prenylated bioactive compounds against various drug targets such as histone deactylases (HDACs), sirtuins (SIRTs), and acetylcholinesterase (AChE), and the molecular molecular interactions between protein and ligand have also been included. Furthermore, the structure-activity relationships (SAR) studies on these compounds are highlighted. This review concludes that the prenylated phytochemicals from H. lupulus L., including xanthohumol (XN), isoxanthohumol (IXN), 8-prenylnaringenin (8-PN) and 6-prenylnaringenin (6-PN), have promising roles in human health and may contribute to new drug discovery and development.
Permanent Link: https://hdl.handle.net/11104/0353651