0585938 - ÚEM 2025 RIV CH eng J - Journal Article
Heřmanová, Zuzana - Valihrach, Lukáš - Kriška, Ján - Maheta, M. - Turečková, Jana - Kubista, M. - Anděrová, Miroslava
The deletion of AQP4 and TRPV4 affects astrocyte swelling/volume recovery in response to ischemia-mimicking pathologies.
Frontiers in Cellular Neuroscience. Roč. 18, May (2024), č. článku 1393751. ISSN 1662-5102. E-ISSN 1662-5102
R&D Projects: GA ČR(CZ) GA20-05770S; GA MŠMT(CZ) LX22NPO5107; GA MŠMT(CZ) LM2023050
Institutional support: RVO:68378041
Keywords : aquaporin 4 * transient receptor potential vanilloid 4 * astrocytes * brain edema * ischemia
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.2, year: 2023 ; AIS: 1.393, rok: 2023
Method of publishing: Open access
Result website:
https://www.frontiersin.org/articles/10.3389/fncel.2024.1393751/fullDOI: https://doi.org/10.3389/fncel.2024.1393751

Astrocytic Transient receptor potential vanilloid 4 (TRPV4) channels, together with Aquaporin 4 (AQP4), are suspected to be the key players in cellular volume regulation, and therefore may affect the development and severity of cerebral edema during ischemia. In this study, we examined astrocytic swelling/volume recovery in mice with TRPV4 and/or AQP4 deletion in response to in vitro ischemic conditions, to determine how the deletion of these channels can affect the development of cerebral edema.
Permanent Link: https://hdl.handle.net/11104/0353574