mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells

0585864 - ÚEM 2025 RIV CH eng J - Journal Article
Romanyuk, Nataliya - Šintáková, Kristýna - Arzhanov, Ivan - Horák, Martin - Gandhi, Ch. - Jhanwar-Uniyal, M. - Jendelová, Pavla
mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells.
Frontiers in Cellular Neuroscience. Roč. 18, May (2024). E-ISSN 1662-5102
R&D Projects: GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:68378041
Keywords : neural stem cells * mTOR * proliferation * differentiation * cytoskeletal proteins
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.3, year: 2022
https://www.frontiersin.org/articles/10.3389/fncel.2024.1298182/full

Neural stem cells (NSCs) are essential for both embryonic development and adult neurogenesis, and their dysregulation causes a number of neurodevelopmental disorders, such as epilepsy and autism spectrum disorders. NSC proliferation and differentiation in the developing brain is a complex process controlled by various intrinsic and extrinsic stimuli. The mammalian target of rapamycin (mTOR) regulates proliferation and differentiation, among other cellular functions, and disruption in the mTOR pathway can lead to severe nervous system development deficits. In this study, we investigated the effect of inhibition of the mTOR pathway by rapamycin (Rapa) on NSC proliferation and differentiation.
Permanent Link: https://hdl.handle.net/11104/0353515