Circadian dysfunction and cardio-metabolic disorders in humans

0585754 - FGÚ 2025 RIV CH eng J - Journal Article
Marhefková, N. - Sládek, Martin - Sumová, Alena - Dubský, M.
Circadian dysfunction and cardio-metabolic disorders in humans.
Frontiers in Endocrinology. Roč. 15, 29 April (2024), č. článku 1328139. ISSN 1664-2392. E-ISSN 1664-2392
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:67985823
Keywords : circadian clock * circadian rhythm disruption * cardiovascular disease risk * type 2 diabetes mellitus * insulin sensitivity * glucose tolerance * time restricted eating
OECD category: Physiology (including cytology)
Impact factor: 5.2, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fendo.2024.1328139

The topic of human circadian rhythms is not only attracting the attention of clinical researchers from various fields but also sparking a growing public interest. The circadian system comprises the central clock, located in the suprachiasmatic nucleus of the hypothalamus, and the peripheral clocks in various tissues that are interconnected, together they coordinate many daily activities, including sleep and wakefulness, physical activity, food intake, glucose sensitivity and cardiovascular functions. Disruption of circadian regulation seems to be associated with metabolic disorders (particularly impaired glucose tolerance) and cardiovascular disease. Previous clinical trials revealed that disturbance of the circadian system, specifically due to shift work, is associated with an increased risk of type 2 diabetes mellitus. This review is intended to provide clinicians who wish to implement knowledge of circadian disruption in diagnosis and strategies to avoid cardio-metabolic disease with a general overview of this topic.
Permanent Link: https://hdl.handle.net/11104/0353434