Changes in cardiovascular autonomic control induced by chronic inhibition of acetylcholinesterase during pyridostigmine or donepezil treatment of spontaneously hypertensive rats

0585351 - FGÚ 2025 RIV NL eng J - Journal Article
Bencze, Michal - Boroš, Almoš - Behuliak, Michal - Vavřínová, Anna - Vaněčková, Ivana - Zicha, Josef
Changes in cardiovascular autonomic control induced by chronic inhibition of acetylcholinesterase during pyridostigmine or donepezil treatment of spontaneously hypertensive rats.
European Journal of Pharmacology. Roč. 971, 15 May (2024), č. článku 176526. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA ČR(CZ) GA21-03810S
Institutional support: RVO:67985823
Keywords : parasympathetic tone * sympathetic tone * sympathovagal control of heart rate * spontaneously hypertensive rats * Wistar-Kyoto rats * acetylcholinesterase inhibitors
OECD category: Physiology (including cytology)
Impact factor: 5, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejphar.2024.176526

Chronic treatment with acetylcholinesterase inhibitors may be a promising therapeutic strategy for treatment of cardiovascular diseases. The aim of our study was to analyze the changes in blood pressure (BP) and heart rate (HR) during 14 days of treatment with two different acetylcholinesterase inhibitors – pyridostigmine (PYR) having only peripheral effects or donepezil (DON) with both peripheral and central effects. In addition, we studied their effects on the cardiovascular response to restraint stress and on sympathovagal control of HR in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). SHR were characterized by elevated BP and increased low-frequency component of systolic BP variability (LF-SBPV), but their cardiac vagal tone and HR variability (HRV) were reduced compared with WKY. Chronic treatment with either acetylcholinesterase inhibitor decreased HR and increased HRV in both strains. PYR treatment slightly decreased BP and LF-SBPV in the dark phase of the day. Neither drug significantly altered BP response to stress, but PYR attenuated HR increase during restraint stress. Regarding sympathovagal balance, acute methylatropine administration caused a greater increase of HR in WKY than in SHR. Chronic PYR or DON treatment enhanced HRV and HR response to methylatropine (vagal tone) in WKY, whereas PYR but not DON treatment potentiated HRV and vagal tone in SHR. In conclusion, vagal tone was lower in SHR compared with WKY, but was enhanced by chronic PYR treatment in both strains. Thus, chronic peripheral, but not central, acetylcholinesterase inhibition has major effects on HR and its variability in both normotensive and hypertensive rats.
Permanent Link: https://hdl.handle.net/11104/0353070