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BODIPY phototether enables oligonucleotide cyclization and subsequent deprotection by tissue-transparent red light
- 1.0585168 - ÚOCHB 2025 RIV GB eng J - Journal Article
Wohlrábová, Lucie - Sahlbach, M. - Heckel, A. - Slanina, Tomáš
BODIPY phototether enables oligonucleotide cyclization and subsequent deprotection by tissue-transparent red light.
Chemical Communications. Roč. 60, č. 32 (2024), s. 4366-4369. ISSN 1359-7345. E-ISSN 1364-548X
R&D Projects: GA ČR(CZ) GA22-20319S
Institutional support: RVO:61388963
Keywords : photo-tethers * oxygen
OECD category: Organic chemistry
Impact factor: 4.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1039/D4CC00272E
meso-methyl-BODIPY photocages release a leaving group upon visible light irradiation but often lack thermal stability. In turn, our thermally-stable, red-shifted BODIPY phototether allows oligonucleotide cyclization, preventing complementary strand hybridization. Hybridization resumes upon red-NIR irradiation, disconnecting the phototether by oxidative cleavage, which is easily monitored by a blue shift in fluorescence.
Permanent Link: https://hdl.handle.net/11104/0352912
Number of the records: 1