Alpha-spinasterol in the roots of Impatiens glandulifera and its effects on the viability of human cells

0584900 - ÚVGZ 2025 RIV DE eng J - Journal Article
Vrchotová, Naděžda - Doudová, L. - Bednář, Jan - Tříska, Jan
Alpha-spinasterol in the roots of Impatiens glandulifera and its effects on the viability of human cells.
Chemical Papers. Roč. 78, č. 5 (2024), s. 3389-3397. ISSN 0366-6352
R&D Projects: GA MŠMT(CZ) EF16_019/0000797
Institutional support: RVO:86652079
Keywords : seed oil * chemical-constituents * allelopathic activity * leaves * identification * phytosterols * extracts * sterols * hexane * benth * Impatiens glandulifera * Roots * alpha-Spinasterol * Cytotoxicity
OECD category: Environmental sciences (social aspects to be 5.7)
Impact factor: 2.2, year: 2022
Method of publishing: Open access
https://link.springer.com/article/10.1007/s11696-024-03335-3?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot

The roots of Impatiens glandulifera belong to plants, or part of plants with a high content of alpha-spinasterol. Chromatographic analysis of roots hexane extract using GC-MS revealed that alpha-spinasterol is the dominant substance in the freeze-dried roots of Impatiens glandulifera and its content reaches ca. 1 wt%. When the hexane extracts are concentrated, alpha-spinasterol crystals fall out in the form of tiny needles, so the isolation of this substance from the roots of Impatiens glandulifera is very easy. Regarding the easy isolation and usage of phytosterols as anticancer and antimicrobial agents, cytotoxicity tests were performed using hepatic Hep G2 cells and blood HL-60 cells. Since hexane is an organic solvent, the cytotoxicity of the used hexane concentrations was measured, too.
Permanent Link: https://hdl.handle.net/11104/0353622