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Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine

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    0584265 - BC 2024 RIV DE eng J - Journal Article
    Yan, X. - Zhao, F. - Wang, G. - Wang, Z. - Zhou, Ming-Xi - Zhang, L. - Wang, G. - Chen, Y.
    Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine.
    Bulletin of Environmental Contamination and Toxicology. Roč. 110, č. 1 (2023), č. článku 12. ISSN 0007-4861. E-ISSN 1432-0800
    Institutional support: RVO:60077344
    Keywords : L-lysine * Microcystis aeruginosa * Microcystin * Metabolomic analysis * Arginine metabolism * Ornithine-ammonia cycle
    OECD category: Biochemistry and molecular biology
    Impact factor: 2.7, year: 2022
    Method of publishing: Limited access
    https://link.springer.com/article/10.1007/s00128-022-03658-5

    The widespread occurrence of cyanobacteria blooms damages the water ecosystem and threatens the safety of potable water and human health. Exogenous L-lysine significantly inhibits the growth of a dominant cyanobacteria Microcystis aeruginosa in freshwater. However, the molecular mechanism of how lysine inhibits the growth of M. aeruginosa is unclear. In this study, both non-target and target metabolomic analysis were performed to investigate the effects of algicide L-lysine. The results showed that 8 mg L- 1 lysine most likely disrupts the metabolism of amino acids, especially the arginine and proline metabolism. According to targeted amino acid metabolomics analysis, only 3 amino acids (L-arginine, ornithine, and citrulline), which belong to the ornithine-ammonia cycle (OAC) in arginine metabolic pathway, showed elevated levels. The intracellular concentrations of ornithine, citrulline, and arginine increased by 115%, 124%, and 19.4%, respectively. These results indicate that L-lysine may affect arginine metabolism and OAC to inhibit the growth of M. aeruginosa.
    Permanent Link: https://hdl.handle.net/11104/0352340

     
     
Number of the records: 1  

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