Improved electro-destruction of bacterial biofilms by coating conductive surfaces with polymers

0584110 - ÚMCH 2025 RIV GB eng J - Journal Article
Hoang, Stéphane - Zhukouskaya, Hanna - Ivanko, Iryna - Svoboda, Jan - Hympánová, M. - Marek, J. - Soukup, O. - Šlouf, Miroslav - Kotek, J. - Doris, E. - Gravel, E. - Tomšík, Elena - Hrubý, Martin
Improved electro-destruction of bacterial biofilms by coating conductive surfaces with polymers.
European Polymer Journal. Roč. 209, 15 April (2024), č. článku 112910. ISSN 0014-3057. E-ISSN 1873-1945
R&D Projects: GA ČR(CZ) GA21-01090S; GA MŠMT(CZ) LUAUS24272; GA MŠMT(CZ) EH22_008/0004607
Institutional support: RVO:61389013
Keywords : bacteria * biofilm * polymer
Impact factor: 6, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S001430572400171X?via%3Dihub

The formation of biofilm involves cell aggregation and adherence, enveloped by a self-produced extracellular matrix. In the medical domain, biofilm-associated infections pose significant challenges, especially concerning implants. This investigation focuses on enhancing electromediated bacterial biofilm eradication through polymer coatings on the anode. These coatings catalyze reactive oxygen species (ROS) generation or convert hydrophobic coatings to bactericidal hydrophilic polycations, detaching the biofilms that are predominantly polyanionic. The first approach employs a metallized polytetrathienylporphyrin layer with ROS catalytic capability, while the second involves an insoluble hydrophobic polyamide, which, upon oxidation, transforms into a bactericidal hydrolytically degradable polycation. Both approaches show promising efficacy in augmenting electromediated Staphylococcus aureus biofilm destruction.
Permanent Link: https://hdl.handle.net/11104/0352482