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Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization
- 1.0583702 - BFÚ 2024 RIV US eng J - Journal Article
Coulon, Rémi - Papoušková, B. - Mohammadi, E. - Otyepka, M. - Wunnava, S. - Šponer, Jiří - Šponer, Judit E.
Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization.
Chembiochem. Roč. 24, č. 24 (2023). ISSN 1439-4227. E-ISSN 1439-7633
R&D Projects: GA ČR(CZ) GA22-25057S
Institutional support: RVO:68081707
Keywords : formamide * phosphorylation * nucleosides * 1st * cyclization * formamide * nucleotides * prebiotic chemistry * rna
OECD category: Biochemistry and molecular biology
Impact factor: 2.6, year: 2023
Method of publishing: Open access
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300510
3',5'-Cyclic nucleotides play a fundamental role in modern biochemical processes and have been suggested to have played a central role at the origin of terrestrial life. In this work, we suggest that a formamide-based systems chemistry might account for their availability on the early Earth. In particular, we demonstrate that in a liquid formamide environment at elevated temperatures 3',5'-cyclic nucleotides are obtained in good yield and selectivity upon intramolecular cyclization of 5'-phosphorylated nucleosides in the presence of carbodiimides.
Permanent Link: https://hdl.handle.net/11104/0351698
Number of the records: 1