Quadruplexes and aging: G4-binding proteins regulate the presence of miRNA in small extracellular vesicles (sEVs)

0583599 - BFÚ 2024 RIV NL eng J - Journal Article
Brázda, Václav - Mergny, Jean-Louis
Quadruplexes and aging: G4-binding proteins regulate the presence of miRNA in small extracellular vesicles (sEVs).
Biochimie. Roč. 214, NOV 2023 (2023), s. 69-72. ISSN 0300-9084. E-ISSN 1638-6183
R&D Projects: GA MŠMT EF15_003/0000477; GA ČR(CZ) GA22-21903S
Institutional support: RVO:68081707
Keywords : small-molecule * translation * mechanism * insights * biology * binding * dna * RNA-Binding protein * Exosome
OECD category: Biochemistry and molecular biology
Impact factor: 3.9, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0300908423000147?via%3Dihub

The interaction between proteins and nucleic acids is a core element of life. Many proteins bind nucleic acids via a sequence-specific manner, but there are also many types of proteins that recognize various structural motifs. Researchers have recently found that proteins that can recognize DNA and RNA G-quadruplexes (G4s) are very important for basic cellular processes, particularly in eukaryotes. Some of these proteins are located outside the nucleus and interact with RNA, potentially affecting miRNA functions in intercellular communication, which is facilitated by small extracellular vesicles (sEVs). Im-balances in the production of sEVs are associated with various pathologies and senescence in humans. The distribution of miRNA into sEVs is regulated by two RNA-binding proteins, Alyref and FUS. Both proteins possess G-rich recognition motifs that are compatible with the formation of RNA parallel G4 structures. This lends credence to the new hypothesis that G4-formation in RNAs and their interaction with G4-binding proteins can affect the fate of miRNAs and control their distribution in sEVs that are associated with senescence and aging.(c) 2023 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
Permanent Link: https://hdl.handle.net/11104/0351605