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Epitranscriptomic regulatory mechanisms, cardiomyocyte physiology, and nonconventional cardioprotective interventions
- 1.0583496 - FGÚ 2024 RIV US eng A - Abstract
Hlaváčková, Markéta - Benák, Daniel - Sotáková-Kašparová, Dita - Holzerová, Kristýna - Hrdlička, Jaroslav - Telenský, P. - Šimonová, Anna - Cahová, Hana - Pecinová, Alena - Eckhardt, Adam - Olsen, M. - Kobets, Tetyana - Neckář, Jan - Kolář, František
Epitranscriptomic regulatory mechanisms, cardiomyocyte physiology, and nonconventional cardioprotective interventions.
European Journal of Clinical Investigation. Wiley. Roč. 53, Suppl.1 (2023), č. článku 57ASM-142. ISSN 0014-2972. E-ISSN 1365-2362.
[ANNUAL SCIENTIFIC MEETING /57./. 07.06.2023-09.06.2023, Praha]
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : ischemic heart disease * ischemia * epitranscriptomics
OECD category: Cardiac and Cardiovascular systems
https://onlinelibrary.wiley.com/doi/10.1111/eci.13992
Our study indicate that maternal diabetes and Hif1a deficiency have combinatorial effects on the development of the cardiac sympathetic nervous system. Consequently, HIF1a dysregulation may contribute to various sympathetic abnormalities underlying cardiac pathologies, including heart failure and sudden cardiac death. These findings highlight the importance of consid-ering maternal health and genetic factors in the develop-ment of adverse cardiac outcomes in offspring.
Permanent Link: https://hdl.handle.net/11104/0351461
Number of the records: 1