Biocompatibility of colloidal polypyrrole

0583313 - BFÚ 2024 RIV NL eng J - Journal Article
Kacerova, S. - Víchová, Z. - Valaskova, K. - Vícha, J. - Münster, L. - Kašpárková, V. - Vašíček, Ondřej - Humpolíček, P.
Biocompatibility of colloidal polypyrrole.
Colloids and Surfaces B-Biointerfaces. Roč. 232, December 2023 (2023), č. článku 113605. ISSN 0927-7765. E-ISSN 1873-4367
Institutional support: RVO:68081707
Keywords : antioxidant activity * conducting polymers * polyaniline * polymerization * nanoparticles * cytotoxicity * dispersions
OECD category: Biophysics
Impact factor: 5.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0927776523004836?via%3Dihub

The excellent electroconductive properties of polypyrrole (PPy) predetermine its use as cell-instructive or bio-sensing biomaterial. PPy has potential for application in a physiological environment, and here the cytotoxicity, antioxidant capacity, modulation of neutrophil oxidative burst, antibacterial activity of colloidal PPy stabilized with polyvinylpyrrolidone (PVP), and long-term stability under physiological conditions are reported. Besides, long-term stability under physiological conditions is also provided. The formation of PPy/PVP colloid was proven by UV-Vis and IR spectroscopy, and its morphology and particle size were detected. The results of cytotoxicity studies show that the safe PPy concentration in colloidal particles for biomedical usage is <= 200 mu g mL-1. In these concentrations, the PPy/PVP also exhibits excellent antioxidant properties and modulates the immune response. The minimal inhibitory concentration of 234 mu g mL-1 was determined against Staphylococcus aureus and Escherichia coli, respectively. The low cytotoxicity and bioactivity of the colloidal PPy/PVP demonstrate their long-term potential for a variety of applications
Permanent Link: https://hdl.handle.net/11104/0351302