0583159 - ÚOCHB 2025 RIV US eng J - Journal Article
Kriegelstein, Michal - Nováková, Gabriela - Marek, Aleš
Synthesis of [3H]Org24598 using in-house prepared [3H]MeI.
Journal of Labelled Compounds and Radiopharmaceuticals. Roč. 67, č. 3 (2024), s. 91-103. ISSN 0362-4803. E-ISSN 1099-1344
Institutional support: RVO:61388963
Keywords : [3H]fluoxetine * [3H]methylation * [3H]methyl iodide preparation * [3H]Org24598 * [3H]thioanisol * COware gas reactor * GlyT1 inhibitor
OECD category: Analytical chemistry
Impact factor: 1.8, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/jlcr.4084

The synthesis of tritium-labelled glycine transporter 1 inhibitor Org24598 is reported. Because of the instability of the Org24598 skeleton under hydrogenation conditions, a synthetic approach using an in-house prepared tritium-labelled alkylating agent ([3H]MeI, SA = 26.2 Ci/mmol) was employed. Alternative methods of labelling are discussed.
Permanent Link: https://hdl.handle.net/11104/0351151