Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction

0583041 - ÚOCHB 2025 RIV US eng J - Journal Article
Amador, R. - Vasseur, J. J. - Birkuš, Gabriel - Bignon, E. - Monari, A. - Clave, G. - Smietana, M.
Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction.
Organic Letters. Roč. 26, č. 4 (2024), s. 819-823. ISSN 1523-7060. E-ISSN 1523-7052
Institutional support: RVO:61388963
Keywords : C-DI-GMP * 2nd-messenger * resistant
Impact factor: 5.2, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.orglett.3c03908

The stimulator of interferon genes (STING) protein plays a crucial role in the activation of the innate immune response. Activation of STING is initiated by cyclic dinucleotides (CDNs) which prompted the community to synthesize structural analogues to enhance their biological properties. We present here the synthesis and biological evaluation of four novel CDN analogues composed of an N-acylsulfonamide linkage. These CDNs were obtained in high overall yields via the sulfo-click reaction as a key step.
Permanent Link: https://hdl.handle.net/11104/0351083