Number of the records: 1
活化STING转接蛋白的具有膦酸酯键的3’3’环状二核苷酸
- 1.0582885 - ÚOCHB 2024 RIV chi P - Patent Document
Birkuš, Gabriel - Páv, Ondřej - Jandušík, Tomáš - Rosenberg, Ivan - Nencka, Radim
活化STING转接蛋白的具有膦酸酯键的3’3’环状二核苷酸.
[3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein.]
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 29.09.2023. Patent Number: CN111566120. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : STING * cyclic dinucleotide (CDN) * cancer
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/065244414/publication/CN111566120B?q=CN111566120B
本文中提供通式J的3'3'环状膦酸酯二核苷酸、其药学上可接受的盐、含有其的医药组合物及所述物质与其他药剂或药品的组合。本发明还涉及所述化合物用于治疗或预防可通过STING蛋白质调节来改善的疾病或病状、诸如癌症或病毒性疾病、过敏性疾病及炎性疾病的用途。此外,这些物质可用作疫苗中的佐剂。
Provided herein are the 3'3' cyclic phosphonate dinucleotides of general formula J, their pharmaceutically acceptable salts, a pharmaceutical composition containing them and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines
Permanent Link: https://hdl.handle.net/11104/0350926
Number of the records: 1