Antidermatophytic quinolizidine alkaloids from Calpurnia aurea subsp.aurea (Aiton) Benth

0582451 - MBÚ 2024 RIV IT eng J - Journal Article
Wanga, Lucy Aketch - Indieka, A. S. - Matasyoh, J. C.
Antidermatophytic quinolizidine alkaloids from Calpurnia aurea subsp.aurea (Aiton) Benth.
Fitoterapia. Roč. 171, DEC 2023 (2023), č. článku 105698. ISSN 0367-326X. E-ISSN 1873-6971
Institutional support: RVO:61388971
Keywords : fabaceae * Calpurnia aurea subps aurea * Fabaceae * Antidermatophytic activity * Quinolizidine alkaloids * Dermatophytes
OECD category: Microbiology
Impact factor: 3.4, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0367326X23002733?via%3Dihub

From the leaves and stem bark of the Kenyan medicinal plant Calpurnia aurea subsp. aurea, four previously undescribed quinolizidine alkaloids namely, 2 beta-methoxy-13 alpha-O-(2 '-pyrrolylcarbonyl) virgiline, 2 alpha-methoxy-13 beta-O-(2 '-pyrrolylcarbonyl) virgiline, 3 alpha-O-angelate-2 beta-hydroxy-13 alpha-O-(2 '-pyrrolylcarbonyl) virgiline, 2,3-dehydrovirgiline were isolated together with four known ones. Structural elucidation of the compounds was based on 1D and 2D NMR spectroscopy and mass spectrometry. Their relative configurations were determined by NOESY correlations and literature. The quinolizidine alkaloids were tested against Trichophyton rubrum, Trichophyton interdigitale, Trichophyton benhamiae, Microsporum canis and Nannizzia gypsea, common causative agents of most of the tinea infections in human. All the isolated quinolizidine alkaloids exhibited antidermatophytic activity with MIC ranging from 37.5 mu g/ml to 300 mu g/ml.
Permanent Link: https://hdl.handle.net/11104/0350524