The activation of dormant ependymal cells following spinal cord injury

0581951 - ÚEM 2024 RIV GB eng J - Journal Article
Rodriguez-Jiménez, F.J. - Jendelová, Pavla - Erceg, Slaven
The activation of dormant ependymal cells following spinal cord injury.
Stem Cell Research & Therapy. Roč. 14, č. 1 (2023), č. článku 175. E-ISSN 1757-6512
R&D Projects: GA MŠMT(CZ) EF15_003/0000419
Institutional support: RVO:68378041
Keywords : spinal cord injury * ependymal cells * activation * regeneration
OECD category: Neurosciences (including psychophysiology
Impact factor: 7.5, year: 2022
Method of publishing: Open access
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-023-03395-4

Ependymal cells, a dormant population of ciliated progenitors found within the central canal of the spinal cord, undergo significant alterations after spinal cord injury (SCI). Understanding the molecular events that induce ependymal cell activation after SCI represents the first step toward controlling the response of the endogenous regenerative machinery in damaged tissues. This response involves the activation of specific signaling pathways in the spinal cord that promotes self-renewal, proliferation, and differentiation. We review our current understanding of the signaling pathways and molecular events that mediate the SCI-induced activation of ependymal cells by focusing on the roles of some cell adhesion molecules, cellular membrane receptors, ion channels (and their crosstalk), and transcription factors. An orchestrated response regulating the expression of receptors and ion channels fine-tunes and coordinates the activation of ependymal cells after SCI or cell transplantation. Understanding the major players in the activation of ependymal cells may help us to understand whether these cells represent a critical source of cells contributing to cellular replacement and tissue regeneration after SCI. A more complete understanding of the role and function of individual signaling pathways in endogenous spinal cord progenitors may foster the development of novel targeted therapies to induce the regeneration of the injured spinal cord
Permanent Link: https://hdl.handle.net/11104/0351138