Biomedical potential of hydrothermally synthesized zinc oxide nanoparticles for antifungal evaluation and cytotoxicity analysis

0581763 - FZÚ 2024 RIV US eng J - Journal Article
Guleria, G. - Kumar, S. - Thakur, S. - Sharma, Dhananjay K. - Thakur, Sh. - Kalia, S. - Shandilya, M.
Biomedical potential of hydrothermally synthesized zinc oxide nanoparticles for antifungal evaluation and cytotoxicity analysis.
Applied Organometallic Chemistry. Roč. 37, č. 12 (2023), č. článku e7270. ISSN 0268-2605. E-ISSN 1099-0739
Grant - others:AV ČR(CZ) CSIR-23-05
Program: Bilaterální spolupráce
Research Infrastructure: CzechNanoLab II - 90251
Institutional support: RVO:68378271
Keywords : antimycotic property * HEK293 cell line * hydrothermal synthesis * ZnO
OECD category: Nano-materials (production and properties)
Impact factor: 3.9, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/aoc.7270

As nanotechnology gains popularity in medicine, there is a growing concern that small nanoparticles (NPs) could accumulate and penetrate deep into the human body, posing potential risks to various organs. To ensure safe usage and assess potential hazards, it is crucial to conduct a toxicological evaluation of ZnO NPs on human organs such as the kidney. The present study involved the synthesis of ZnO NPs by using the hydrothermal method. Two pathogenic fungi Fusarium incarnatum and Aspergillus niger were isolated from the capsicum and tomato, respectively, and identified through morphological and molecular analysis. The antimycotic property of synthesized ZnO NPs were examined against Fusariumincarnatum (MT682502) and Aspergillus niger (MT675916) and showed decreased microbial growth after 9 days of incubation. The toxicological evaluation of ZnO NPs on a human embryonic kidney (HEK293) cell line showed 88% cell viability with 10 μg/ml, leading to the safe use of ZnO NPs.
Permanent Link: https://hdl.handle.net/11104/0350141