0580669 - ÚOCHB 2024 RIV jpn P - Patent Document
Šimková, Adéla - Šácha, Pavel - Sidej, Natan - Ormsby, Tereza - Konvalinka, Jan
線維芽細胞活性化タンパク質を阻害するための化合物.
[Compounds for inhibition of fibroblast activation protein.]
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 24.10.2023. Patent Number: JP7368637. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA ČR(CZ) GA19-10280S; GA MZd(CZ) NV15-31379A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2015064; GA MZd(CZ) NU22-03-00318; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : FAP * protease * inhibition
OECD category: Medicinal chemistry
Result website:
https://worldwide.espacenet.com/patent/search/family/075953813/publication/JP7368637B2?q=JP7368637B2

本発明は、親和性および阻害効果において既知のＦＡＰ阻害剤をはるかに超える一般式Ｉのキノリンカルボキサミド化合物を提供する。これらの薬剤は、診断および治療の目的のために腫瘍を特異的に標的とするために、または内因性ＦＡＰ発現の研究における実験室目的のために、使用することができる

This invention provides quinolinecarboxamide compounds of general formula I which by far exceed the previously known FAP inhibitors in affinity and inhibitory effect. These agents can be used to specifically target tumours for diagnostic and therapeutic purposes, or for laboratory purposes in the study of endogenous FAP expression.
Permanent Link: https://hdl.handle.net/11104/0349430