Compounds for inhibition of fibroblast activation protein

0580664 - ÚOCHB 2024 RIV eng P - Patent Document
Šimková, Adéla - Šácha, Pavel - Sidej, Natan - Ormsby, Tereza - Konvalinka, Jan
Compounds for inhibition of fibroblast activation protein.
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 27.09.2023. Patent Number: EP4126841. Territorial Protection: evropský patent podle Evropské patentové úmluvy ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA ČR(CZ) GA19-10280S; GA MZd(CZ) NV15-31379A; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2015064; GA MZd(CZ) NU22-03-00318; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : FAP * protease * inhibition
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/075953813/publication/EP4126841B1?q=EP4126841B1

This invention provides quinolinecarboxamide compounds of general formula I which by far exceed the previously known FAP inhibitors in affinity and inhibitory effect. These agents can be used to specifically target tumours for diagnostic and therapeutic purposes, or for laboratory purposes in the study of endogenous FAP expression.
Permanent Link: https://hdl.handle.net/11104/0349428