Application of microfluidic reactor for phase transfer catalysed N-alkylation

0580646 - ÚCHP 2024 eng A - Abstract
Jaklová, Natalie - Klusoň, Petr - Stavárek, Petr - Vychodilová, Hana
Application of microfluidic reactor for phase transfer catalysed N-alkylation.
[European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology /14./. Berlin, 17.09.2023-21.09.2023]
Method of presentation: Poster
Event organizer: DECHEMA e.V.
Institutional support: RVO:67985858
Keywords : microfluidic reactor * N-alkylation * phase transfer catalysis
OECD category: Chemical process engineering

The main topic of the contribution is the transfer of the batch N-alkylation reaction to the continuous regime. This involves the alkylation of the methyl ester of 10αmethoxydihydrolysergic acid (LUME) to form the methyl ester of 1-methyl-10αmethoxydihydrolysergic acid (MeLUME). The chosen methylation reaction is part of the production of Nicergoline, a drug used to promote cognitive function in patients suffering from senile and presenile syndrome of vascular or degenerative origin, or to promote peripheral blood flow.
Permanent Link: https://hdl.handle.net/11104/0349414