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2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
- 1.0580601 - ÚOCHB 2024 RIV eng P - Patent Document
Birkuš, Gabriel - Páv, Ondřej - Jandušík, Tomáš - Rosenberg, Ivan - Nencka, Radim
2'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein.
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 22.11.2023. Patent Number: EP3728282. Territorial Protection: evropský patent podle Evropské patentové úmluvy ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : STING * cyclic dinucleotide * agonist
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/065244413/publication/EP3728282B1?q=EP3728282B1
The present disclosure relates to 2′3′ cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
Permanent Link: https://hdl.handle.net/11104/0349363
Number of the records: 1