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２’３’－環状ジヌクレオチドおよびそのプロドラッ
- 1.0580598 - ÚOCHB 2024 RIV jpn P - Patent Document
Birkuš, Gabriel - Páv, Ondřej - Kostov, Ondřej - Břehová, Petra - Kaiser, Martin Maxmilian - Šimák, Ondřej
２’３’－環状ジヌクレオチドおよびそのプロドラッ.
[2'3'-cyclic dinucleotides and prodrugs thereof.]
2023. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 26.09.2023. Patent Number: JP7350871. Territorial Protection: národní patent v zemi mimo EU ,mezinárodní patentová ochrana dle Smlouvy o patentové spolupráci.
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : STING * cyclic dinucleotide * oncology
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/069845482/publication/JP7350871B2?q=JP7350871B2
本開示は、一般式（Ｉ）の２’３’環状ホスホネートジヌクレオチド、それらの薬学的に許容可能な塩、それらの薬学的組成物、ならびに前記物質および他の医薬品または医薬の組み合わせに関する。本開示はまた、ＳＴＩＮＧタンパク質調節によって改変可能な疾患または状態（例えば、癌またはウイルス、アレルギー性および炎症性疾患）の治療または予防のための上記化合物の使用に関する。さらに、これらの物質は、ワクチンにおけるアジュバントとして使用され得る。【化１
The present disclosure relates to 2'3' cyclic phosphonate dinucleotides of Formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.
Permanent Link: https://hdl.handle.net/11104/0349361
Number of the records: 1