Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes

0580593 - BC 2024 RIV US eng J - Journal Article
Prokopchuk, Galina - Butenko, Anzhelika - Dacks, Joel Bryan - Speijer, D. - Field, Mark Christian - Lukeš, Julius
Lessons from the deep: mechanisms behind diversification of eukaryotic protein complexes.
Biological Reviews. Roč. 98, č. 6 (2023), s. 1910-1927. ISSN 1464-7931. E-ISSN 1469-185X
R&D Projects: GA ČR(CZ) GA20-11585S; GA ČR(CZ) GX23-06479X; GA MŠMT(CZ) EF16_019/0000759
EU Projects: Wellcome Trust(GB) 204697/Z/16/Z
Institutional support: RVO:60077344
Keywords : mitochondrial contact site * cytochrome-c-oxidase * rab gtpase family * respiratory-chain * acanthamoeba-castellanii * trypanosoma-brucei * atp synthase * chlamydomonas-reinhardtii * succinate-dehydrogenase * tethering complexes * molecular evolution * evolutionary mechanisms * gene replacement * constructive neutral evolution * protein complexes * evolutionary divergence
OECD category: Cell biology
Impact factor: 10, year: 2022
Method of publishing: Open access
https://onlinelibrary.wiley.com/doi/10.1111/brv.12988

Genetic variation is the major mechanism behind adaptation and evolutionary change. As most proteins operate through interactions with other proteins, changes in protein complex composition and subunit sequence provide potentially new functions. Comparative genomics can reveal expansions, losses and sequence divergence within protein-coding genes, but in silico analysis cannot detect subunit substitutions or replacements of entire protein complexes. Insights into these fundamental evolutionary processes require broad and extensive comparative analyses, from both in silico and experimental evidence. Here, we combine data from both approaches and consider the gamut of possible protein complex compositional changes that arise during evolution, citing examples of complete conservation to partial and total replacement by functional analogues. We focus in part on complexes in trypanosomes as they represent one of the better studied non-animal/non-fungal lineages, but extend insights across the eukaryotes by extensive comparative genomic analysis. We argue that gene loss plays an important role in diversification of protein complexes and hence enhancement of eukaryotic diversity.
Permanent Link: https://hdl.handle.net/11104/0349356