Cultivation of microorganisms in bioreactors

0580569 - ÚCHP 2024 RIV CZ eng J - Journal Article
Terentyak, Mark - Sýkora, V. - Zedníková, Mária
Cultivation of microorganisms in bioreactors.
Bioprospect. Roč. 33, č. 4 (2023), s. 57-67. ISSN 1210-1737
Institutional support: RVO:67985858
Keywords : bioreactor * bubble column * stirred tank * cultivation
OECD category: Chemical process engineering
Method of publishing: Open access

Industrial cultivations are a key source of many products. Each cultivation requires a specific producing organism, conditions and
apparatus. Stirred tanks are most commonly used bioreactors, due to their efficient homogenization and versatility. However, they are
not entirely suitable for cultivation of shear sensitive cells. Bubble columns are more suitable option for shear sensitive cells. Overall
comparison of bubble columns and stirred tanks is complicated, since every cultivation is situational.
Bubble columns are simple and easy to build bioreactors, which require a smaller starting investment compared to STRs. In the case
of BCs without the internals, they required less maintenance due to lack of complex mechanical parts. However, BCs are not as ver‑
satile as STRs and are much more situational. Even though, they are unreplaceable part of today’s industry, especially in cultivations
of shear sensitive cells in high volumes, like production of citric acid or antibiotics.
Direct comparison of BC and STR is difficult. Some studies have conducted tests with specific cultivations on minds. Still, the final
choice between these bioreactors depends on application, cell line used and final economics of the entire process.
Permanent Link: https://hdl.handle.net/11104/0349330