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Cultivation of microorganisms in bioreactors

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    0580569 - ÚCHP 2024 RIV CZ eng J - Journal Article
    Terentyak, Mark - Sýkora, V. - Zedníková, Mária
    Cultivation of microorganisms in bioreactors.
    Bioprospect. Roč. 33, č. 4 (2023), s. 57-67. ISSN 1210-1737
    Institutional support: RVO:67985858
    Keywords : bioreactor * bubble column * stirred tank * cultivation
    OECD category: Chemical process engineering
    Method of publishing: Open access

    Industrial cultivations are a key source of many products. Each cultivation requires a specific producing organism, conditions and
    apparatus. Stirred tanks are most commonly used bioreactors, due to their efficient homogenization and versatility. However, they are
    not entirely suitable for cultivation of shear sensitive cells. Bubble columns are more suitable option for shear sensitive cells. Overall
    comparison of bubble columns and stirred tanks is complicated, since every cultivation is situational.
    Bubble columns are simple and easy to build bioreactors, which require a smaller starting investment compared to STRs. In the case
    of BCs without the internals, they required less maintenance due to lack of complex mechanical parts. However, BCs are not as ver‑
    satile as STRs and are much more situational. Even though, they are unreplaceable part of today’s industry, especially in cultivations
    of shear sensitive cells in high volumes, like production of citric acid or antibiotics.
    Direct comparison of BC and STR is difficult. Some studies have conducted tests with specific cultivations on minds. Still, the final
    choice between these bioreactors depends on application, cell line used and final economics of the entire process.
    Permanent Link: https://hdl.handle.net/11104/0349330

     
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    SKMBT_C22024011010510.pdf27.5 MBPublisher’s postprintopen-access
     
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